TABLE 2.
MTAP Immunostaining and Tumor Phenotype
| Entity | Pathologic parameters | n | MTAP status (%)* | P | ||
|---|---|---|---|---|---|---|
| Loss | Retained | |||||
| HCC | Tumor stage | pT1 | 77 | 6.5 | 93.5 | 0.0911 |
| pT2 | 83 | 10.8 | 89.2 | — | ||
| pT3-pT4 | 59 | 18.6 | 81.4 | — | ||
| Nodal stage | pN0 | 74 | 10.8 | 89.2 | 0.0349 | |
| pN+ | 42 | 26.2 | 73.8 | — | ||
| Grade | G1 | 36 | 0.0 | 100.0 | 0.0156 | |
| G2 | 128 | 10.9 | 89.1 | — | ||
| G3 | 52 | 13.5 | 86.5 | — | ||
| NETs† | Tumor stage | pT1 | 28 | 35.7 | 64.3 | 0.0166 |
| pT2 | 24 | 37.5 | 62.5 | — | ||
| pT3 | 36 | 47.2 | 52.8 | — | ||
| pT4 | 32 | 71.9 | 28.1 | — | ||
| Nodal stage | pN0 | 45 | 37.8 | 62.2 | 0.0946 | |
| pN+ | 59 | 54.2 | 45.8 | — | ||
| Pancreatic adenocarcinoma | Tumor stage | pT1 | 7 | 14.3 | 85.7 | 0.6582 |
| pT2 | 59 | 28.8 | 71.2 | — | ||
| pT3 | 316 | 29.7 | 70.2 | — | ||
| pT4 | 24 | 37.5 | 62.5 | — | ||
| Nodal stage | pN0 | 81 | 33.3 | 66.7 | 0.4091 | |
| pN+ | 325 | 28.6 | 71.4 | — | ||
| Grade | G1 | 16 | 18.8 | 81.3 | 0.3964 | |
| G2 | 282 | 31.2 | 68.8 | — | ||
| G3 | 88 | 26.1 | 73.9 | — | ||
| Invasive breast cancer of no special type | Tumor stage | pT1 | 162 | 0.0 | 100.0 | 0.1019 |
| pT2 | 194 | 1.5 | 98.5 | — | ||
| pT3-pT4 | 35 | 2.9 | 97.1 | — | ||
| Nodal stage | pN0 | 198 | 0.5 | 99.5 | 0.8765 | |
| pN+ | 98 | 0.6 | 99.4 | — | ||
| Grade | G1 | 13 | 0.0 | 100.0 | 0.0268 | |
| G2 | 221 | 0.0 | 100.0 | — | ||
| G3 | 161 | 2.5 | 97.5 | — | ||
| SQCCs‡ | Tumor stage | pT1 | 235 | 10.6 | 89.4 | 0.0299 |
| pT2 | 250 | 10.0 | 90.0 | — | ||
| pT3 | 121 | 19.0 | 81.0 | — | ||
| pT4 | 125 | 17.6 | 82.4 | — | ||
| Nodal stage | pN0 | 276 | 12.0 | 88.0 | 0.0615 | |
| pN+ | 285 | 17.5 | 82.5 | — | ||
| Grade | G1 | 30 | 0.0 | 100.0 | 0.0034 | |
| G2 | 341 | 15.0 | 85.0 | — | ||
| G3 | 234 | 9.8 | 90.2 | — | ||
| HPV | Negative | 275 | 18.2 | 81.8 | <0.0001 | |
| Positive | 233 | 5.6 | 94.4 | — | ||
*
MTAP loss: no MTAP immunostaining, MTAP retained: MTAP 1+ to 3+ immunostaining.
†
Neuroendocrine tumors of the appendix, colorectum, ileum, pancreas, and lung.
‡
Squamous cell carcinomas of the oral cavity (n = 119), pharynx (n = 59), larynx (n = 82), esophagus (n = 36), lung (n = 59), cervix (n = 1139), vagina (n = 54), vulva (n = 100), penis (n = 77), skin (n = 68), and the anal canal (n = 78).
HPV indicates human papillomavirus.