TABLE 3.
MTAP Immunostaining and HPV Status in SQCCs of Various Origins
| Tumor entity | HPV status | n | MTAP status (%)* | P | |
|---|---|---|---|---|---|
| Loss | Retained | ||||
| Oral squamous cell carcinoma | Negative | 66 | 15.2 | 84.8 | 0.0578 |
| Positive | 12 | 0.0 | 100.0 | — | |
| Squamous cell carcinoma of the pharynx | Negative | 22 | 13.6 | 86.4 | 0.8368 |
| Positive | 34 | 11.8 | 88.2 | — | |
| Squamous cell carcinoma of the larynx | Negative | 48 | 31.3 | 68.8 | 0.7177 |
| Positive | 8 | 25.0 | 75.0 | — | |
| Squamous cell carcinoma of the cervix | Negative | 9 | 22.2 | 77.8 | 0.0028 |
| Positive | 67 | 0.0 | 100.0 | — | |
| Squamous cell carcinoma of the vagina | Negative | 15 | 26.7 | 73.3 | 0.4638 |
| Positive | 13 | 15.4 | 84.6 | — | |
| Squamous cell carcinoma of the vulva | Negative | 45 | 24.4 | 75.6 | 0.4485 |
| Positive | 24 | 16.7 | 83.3 | — | |
| Squamous cell carcinoma of the penis | Negative | 29 | 3.4 | 96.6 | 0.7537 |
| Positive | 45 | 2.2 | 97.8 | — | |
| Squamous cell carcinoma of the skin | Negative | 36 | 8.3 | 91.7 | 0.6787 |
| Positive | 1 | 0.0 | 100.0 | — | |
| Squamous cell carcinoma of the anal canal | Negative | 5 | 20.0 | 80.0 | 0.0450 |
| Positive | 29 | 0.0 | 100.0 | — | |
*
MTAP loss: no MTAP immunostaining, MTAP retained: MTAP 1+ to 3+ immunostaining.
HPV indicates human papillomavirus.