Figure 7.

Profile of the fraction of free volume along the membrane normal axis, X, as obtained in the neat DPPC membrane as well as in membranes containing DE (top left), PE (bottom left), CF (top right), and CT (bottom right). Black solid lines: neat DPPC membrane; red circles: membranes with anesthetics; and blue squares: membranes with non-anesthetics. Filled and open symbols correspond to the systems at 1 and 600 bar, respectively. To magnify the effect of the solute molecules, the profiles (being already symmetrized over the two leaflets) are only shown in one side of the membrane.