TABLE 1.
Vmax, Km, and CLint values for the disappearance of clarithromycin in hepatic microsomes of rats with DMIA and DMIS and their respective control ratsa
| Parameter | Value for:
|
|||
|---|---|---|---|---|
| DMIA controls (n = 5) | Rats with DMIA (n = 5) | DMIS controls (n = 5) | Rats with DMIS (n = 5) | |
| Vmax (pmol/min/mg protein) | 121 ± 27.4 | 284 ± 141b | 185 ± 31.7 | 363 ± 150b |
| Km (μM) | 25.6 ± 6.30 | 36.6 ± 10.2 | 41.7 ± 7.03 | 56.2 ± 30.9 |
| CLint (μl/min/mg protein) | 4.83 ± 0.944 | 7.54 ± 1.82b | 4.46 ± 0.300 | 6.93 ± 1.11c |
a
Values shown are means ± standard deviations.
b
P < 0.05 compared with the control.
c
P < 0.01 compared with the control.