TABLE 2.
Pharmacokinetic parameters of clarithromycin after a 1-min intravenous infusion at a dose of 20 mg/kg to rats with DMIA and DMIS and their respective control ratsa
| Parameter | Value for:
|
|||
|---|---|---|---|---|
| DMIA control rats (n = 11) | Rats with DMIA (n = 12) | DMIS control rats (n = 7) | Rats with DMIS (n = 8) | |
| Body weight (g) | ||||
| Initialb | 260 ± 7.07 | 262 ± 8.65 | 268 ± 8.59 | 275 ± 3.78 |
| Finalc | 300 ± 9.61 | 251 ± 21.2d | 324 ± 17.3 | 263 ± 18.1d |
| AUC0-∞ (μg · min/ml) | 502 ± 120 | 371 ± 66.2e | 576 ± 89.5 | 435 ± 87.4e |
| Terminal half-life (min) | 137 ± 39.7 | 138 ± 31.8 | 172 ± 79.1 | 131 ± 20.7f |
| MRT (min) | 93.7 ± 25.5 | 83.1 ± 26.6 | 163 ± 96.6 | 66.9 ± 18.2e |
| Vss (ml/kg) | 3,580 ± 1,260 | 4,390 ± 1,640 | 4,500 ± 2,350 | 2,890 ± 2,700f |
| CL (ml/min/kg) | 39.8 ± 9.23 | 53.8 ± 9.72e | 34.7 ± 4.82 | 46.0 ± 8.79f |
| CLR (ml/min/kg) | 6.78 ± 2.53 | 8.00 ± 3.79 | 7.23 ± 3.02 | 10.2 ± 1.65 |
| CLNR (ml/min/kg) | 31.5 ± 7.09 | 45.3 ± 7.17d | 26.5 ± 3.13 | 35.5 ± 7.66f |
| Ae0-24 h (% of dose) | 18.4 ± 4.38 | 16.0 ± 4.30 | 23.3 ± 7.68 | 22.4 ± 3.39 |
| GI24 h (% of dose) | 0.289 ± 0.147 | 0.166 ± 0.0825 | 0.496 ± 0.534 | 0.280 ± 0.107 |
a
Values shown are means ± standard deviations.
b
Measured just before injection of alloxan, streptozotocin, or respective vehicles.
c
Measured just before starting the experiment.
d
P < 0.001 compared with the control.
e
P < 0.01 compared with the control.
f
P < 0.05 compared with the control.