TABLE 3.
Pharmacokinetic-parameters of clarithromycin after oral administration at a dose of 20 mg/kg to rats with DMIA and DMIS and their respective control ratsa
| Parameter | Value for:
|
|||
|---|---|---|---|---|
| DMIA control rats (n = 11) | Rats with DMIA (n = 9) | DMIS control rats (n = 9) | Rats with DMIS (n = 10) | |
| Body weight (g) | ||||
| Initialb | 248 ± 7.17 | 252 ± 6.12 | 248 ± 5.65 | 257 ± 10.6 |
| Finalc | 271 ± 7.69 | 234 ± 8.94d | 286 ± 20.4 | 236 ± 20.4d |
| AUC0-∞ (μg · min/ml) | 113 ± 33.8 | 74.9 ± 34.7e | 121 ± 44.1 | 85.9 ± 24.4e |
| Terminal half-life (min) | 190 ± 104 | 214 ± 88.4 | 173 ± 44.0 | 112 ± 43.4e |
| Cmax (μg/ml) | 0.462 ± 0.113 | 0.414 ± 0.171 | 0.607 ± 0.205 | 0.655 ± 0.232 |
| CLR (ml/min/kg) | 14.3 ± 5.21 | 15.4 ± 6.10 | 16.0 ± 10.3 | 24.2 ± 11.9 |
| Tmax (min) | 53.2 ± 52.1 | 36.7 ± 26.1 | 21.7 ± 10.9 | 27.0 ± 15.5 |
| Ae0-24 h (% of dose) | 8.58 ± 2.54 | 6.46 ± 4.05 | 10.4 ± 3.45 | 11.5 ± 3.74 |
| GI24 h (% of dose) | 0.363 ± 0.437 | 1.23 ± 1.07 | 0.752 ± 1.02 | 1.36 ± 1.25 |
| F (%) | 22.5 | 20.2 | 21.0 | 19.7 |
a
Values shown are means ± standard deviations.
b
Measured just before injection of alloxan, streptozotocin, or respective vehicles.
c
Measured just before starting the experiment.
d
P < 0.001 compared with the control.
e
P < 0.05 compared with the control.