Table 3.
Mendelian randomization analysis and sensitivity analysis of PAH on Immunocyte.
| Panel | Immunocyte | MR analysis | Heterogeneity | Pleiotropy | AT global outlier test | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Exposure | nSNPs | OR (95% CI) | PFDR | Q | P-value | Intercept | P-value | RSSOBs | P-value | |
| B cell | CD20-B cell %B cell | 6 | 1.04 (1.00–1.07) | 0.035 | 5 | .899 | −0.052 | .318 | 4.052 | .812 |
| cDC | CD62L-HLA DR++ monocyte AC | 6 | 0.96 (0.93–0.99) | 0.026 | 5 | .517 | −0.034 | .520 | 8.425 | .559 |
| cDC | CD62L-HLA DR++ monocyte %monocyte | 6 | 0.96 (0.93–0.99) | 0.026 | 5 | .563 | −0.020 | .706 | 6.671 | .614 |
| TBNK | HLA DR++ monocyte %monocyte | 6 | 0.95 (0.91–0.99) | 0.026 | 5 | .131 | −0.058 | .395 | 18.618 | .275 |
| HLA DR++ monocyte Absolute Count | 6 | 0.96 (0.93–0.99) | 0.026 | 5 | .410 | −0.014 | .796 | 8.000 | .499 | |
| TBNK | HLA DR++ monocyte %leukocyte | 6 | 0.97 (0.93–1.00) | 0.044 | 5 | .330 | −0.047 | .407 | 12.325 | .425 |