. 2005 Jun;49(6):2421–2428. doi: 10.1128/AAC.49.6.2421-2428.2005

TABLE 3.

Summary of imipenem pharmacokinetic parameters for patients receiving CRRT

Patient and therapy	Dosing regimen	C_max (μg/ml)	C_min (μg/ml)	AUC_0-24 (μg · h/ml)	t_1/2 (h)	V (liter/kg)	CL_S^a		CL_NR^a		CRRT CL^a		% CL_S^b	S/S_a^b
Patient and therapy	Dosing regimen	C_max (μg/ml)	C_min (μg/ml)	AUC_0-24 (μg · h/ml)	t_1/2 (h)	V (liter/kg)	ml/min	ml/min/kg	ml/min	ml/min/kg	ml/min	ml/min/kg	% CL_S^b	S/S_a^b
CVVH
1	0.5 g every 12 h	22.8	0.1^c	99.2	1.31	0.28	173 ± 14	2.47 ± 0.20	147 ± 12	2.10 ± 0.17	26 ± 11	0.37 ± 0.14	15	1.16
2	0.5 g every 12 h	18.9	0.3	112.6	1.87	0.32	157 ± 18	1.98 ± 0.23	102 ± 17	1.29 ± 0.21	55 ± 19	0.69 ± 0.21	35	1.31
3	0.5 g every 12 h	16.0	1.8	160.5	3.65	0.43	121 ± 16	1.36 ± 0.18	73 ± 18	0.83 ± 0.20	47 ± 12	0.53 ± 0.16	39	1.18
4	0.5 g every 12 h	12.3	2.3	145.7	4.72	0.51	139 ± 14	1.25 ± 0.12	115 ± 15	1.04 ± 0.13	24 ± 10	0.21 ± 0.09	17	1.34
5	0.5 g every 8 h	15.7	2.3	175.5	2.72	0.36	146 ± 13	1.53 ± 0.14	116 ± 12	1.22 ± 0.12	29 ± 9	0.31 ± 0.16	20	1.03
6	0.5 g every 8 h	21.3	1.5	191.0	1.98	0.25	134 ± 7	1.46 ± 0.08	101 ± 9	1.11 ± 0.10	32 ± 9	0.35 ± 0.10	24	1.25
Mean ± SD		17.8 ± 3.9	1.4 ± 1.0	147.4 ± 35.8	2.71 ± 1.27	0.36 ± 0.10	145 ± 18^d	1.67 ± 0.46^d	109 ± 24^d	1.30 ± 0.44^d	36 ± 13^d	0.41 ± 0.17^d	25 ± 10	1.21 ± 0.11
CVVHDF
7	0.5 g every 12 h	16.2	0.2^c	91.5	1.75	0.33	192 ± 21	2.17 ± 0.24	84 ± 22	0.96 ± 0.25	108 ± 31	1.22 ± 0.32	56	1.26
8	0.5 g every 12 h	10.6	2.5	137.6	5.56	0.58	151 ± 16	1.21 ± 0.13	84 ± 18	0.67 ± 0.14	66 ± 10	0.53 ± 0.15	44	1.39
9	0.5 g every 12 h	15.6	0.3	101.7	2.09	0.37	176 ± 19	2.05 ± 0.22	146 ± 22	1.70 ± 0.26	30 ± 11	0.35 ± 0.12	17	1.28
10	0.5 g every 8 h	18.5	0.4	125.7	1.39	0.29	203 ± 17	2.41 ± 0.20	160 ± 15	1.90 ± 0.18	43 ± 9	0.51 ± 0.15	21	1.03
11	0.5 g every 8 h	12.7	2.4	153.5	3.09	0.45	167 ± 6	1.68 ± 0.06	113 ± 7	1.14 ± 0.07	53 ± 13	0.54 ± 0.24	32	1.17
12	0.5 g every 8 h	20.1	0.6	142.7	1.46	0.21	179 ± 11	1.66 ± 0.10	136 ± 10	1.26 ± 0.09	43 ± 16	0.40 ± 0.13	24	1.52
Mean ± SD		15.6 ± 3.5	1.1 ± 1.1	125.4 ± 24.3	2.56 ± 1.59	0.37 ± 0.13	178 ± 18^d	1.86 ± 0.43^d	120 ± 32^d	1.30 ± 0.46^d	57 ± 28^d	0.59 ± 0.32^d	32 ± 15	1.28 ± 0.17
P value^e		0.309	0.916	0.392	0.860	0.884	0.010	0.477	0.505	1.00	0.109	0.252	0.364	0.417

Values are means ± standard deviations (SD) calculated from parameter values determined during each of the three or four postdose sampling intervals within each patient: 1 to 2 h, 2 to 4 h, 4 to 8 h, and 8 to 12 h (except with 8-h-dosing-interval regimens).

Calculated from mean CRRT clearance for each patient.

Calculated values rather than directly measured.

Means ± standard deviations calculated from means of the three or four parameter values determined within each patient.

Values determined during CVVH regimens versus CVVHDF regimens.