TABLE 1.
Pharmacokinetic parameters (means ± SDs) of linezolid in plasma, muscle, and subcutaneous adipose tissue following single intravenous dose administration of 600 mg
| Compartment | AUC0-8 (mg · h/liter) | AUCtissue/AUCfree plasma | AUC0-24 (mg · h/liter) | Cmax (mg/liter) | Tmax (h) | t1/2 (h) | CL (liters/h) | V (liters) |
|---|---|---|---|---|---|---|---|---|
| Plasma total | 58.1 ± 12.7 | 88.1 ± 34.0 | 14.1 ± 2.8 | 0.5 ± 0.2 | 5.1 ± 2.6 | 7.9 ± 3.2 | 46.3 ± 9.1 | |
| Plasma free | 53.0 ± 11.6 | 80.3 ± 30.9 | 12.8 ± 2.6 | 0.5 ± 0.2 | 5.1 ± 2.6 | NDa | ND | |
| Subcutis | 75.8 ± 24.2b | 1.4 ± 0.3 | 129.7 ± 57.8 | 18.1 ± 4.8 | 0.9 ± 0.3 | 6.1 ± 1.9 | ND | ND |
| Muscle | 65.4 ± 18.2b | 1.3 ± 0.4 | 94.1 ± 35.5 | 13.5 ± 3.3 | 1.1 ± 0.3 | 3.9 ± 1.2 | ND | ND |
a
ND, not determined.
b
P < 0.05 compared with the results for free plasma.