TABLE 2.
Pharmacokinetic parameters (means ± SDs) of linezolid for plasma, muscle, and subcutaneous adipose tissue after multiple oral doses of 600 mg twice a day over a period of three to five consecutive days
| Compartment | AUC0-8 (mg · h/liter) | AUCtissue/AUCfree plasma | AUC0-24 (mg · h/liter) | Cmax (mg/liter) | Tmax (h) | t1/2 (h) |
|---|---|---|---|---|---|---|
| Plasma total | 94.9 ± 24.3 | 244.9 ± 72.3 | 19.5 ± 4.6 | 1.4 ± 1.0 | 6.9 ± 2.6 | |
| Plasma free | 83.9 ± 23.9 | 217.1 ± 71.5 | 17.1 ± 4.0 | 1.4 ± 1.0 | 6.9 ± 2.6 | |
| Subcutis | 71.5 ± 15.3 | 0.9 ± 0.2 | 200.8 ± 53.2 | 12.9 ± 2.4 | 2.2 ± 1.2 | 7.5 ± 2.7 |
| Muscle | 80.2 ± 42.3 | 1.0 ± 0.5 | 235.5 ± 132.1 | 15.4 ± 8.0 | 2.6 ± 1.1 | 6.4 ± 1.8 |