Figure 1. Association of serum granzyme K concentrations with subsequent IgG3 induction in primary dengue patients.

Concentrations of cytokines and T cell–associated immune factors were determined in the serum of pediatric primary dengue patients (n = 29). (A) Correlation matrix showing the correlation between concentrations of cytokines in patient samples at the acute (days 1–3 after fever onset) phase of disease. Heatmap represents the correlation coefficients for each pair of cytokines evaluated. Stronger positive correlations approach 1. (B) Serum concentrations of granzyme K were significantly higher in serum samples obtained 1 to 3 days after fever onset for patients who had detectable anti-DENV IgG3 by days 6 to 7 after fever onset. *P = 0.0495, Mann Whitney U test. IgG3 positivity was defined as having an anti-DENV endpoint ELISA titer 2-fold or greater above that of naive serum.