TABLE 4.
Parameter estimates for the two-population pharmacodynamic model (model 2)a
| Strain | gS (h−1) | gR (h−1) | kS (h−1) | kR (h−1) | EC50,S (μg/ml) | EC50,R (μg/ml) | R0 (CFU/ml) | Nmax (CFU/ml) |
|---|---|---|---|---|---|---|---|---|
| MRSA 8043 | 0.87 (0.09) | 0.72 (0.04) | 1.53 (0.09) | 1.12 (0.04) | 0.20 (0.02) | 0.72 (0.09) | 1.14 (0.76) | 1.1 (0.2) × 109 |
| MRSA 8282 | 0.87 (0.05) | 0.66 (0.02) | 1.47 (0.05) | 1.02 (0.02) | 0.20 (0.01) | 0.75 (0.06) | 1.32 (0.61) | 7.5 (0.8) × 109 |
a
Values are means ± standard errors. EC50,S and EC50,R, EC50 of the S and R subpopulations, respectively; Nmax, carrying capacity of the in vitro system.