TABLE 1.
Effect of LBM415 on L. pneumophila multiplication in guinea pig alveolar macrophages
| Strain or drug and concn (μg/ml) | Log10 (d3/d1ctl) CFU/mla
|
|||
|---|---|---|---|---|
| F889
|
F2111
|
|||
| expt 1 | expt 2 | expt 2 | expt 3 | |
| Control | 0.3 | 1.5 | 2.5 | 2.5 |
| LBM415 | ||||
| 0.125 | 0.7 | NDb | ND | ND |
| 0.25 | 0.2 | −0.1 | 2.5 | ND |
| 0.50 | ND | −0.4 | 2.4 | ND |
| 1 | ND | −0.4 | 2.4 | ND |
| 2 | ND | −0.4 | 2.5 | ND |
| 4 | ND | ND | 2.0 | ND |
| 8 | ND | ND | 1.2 | 0.6 |
| 16 | ND | ND | ND | −0.1 |
| 32 | ND | ND | ND | −0.2 |
| Levofloxacin | ||||
| 1 | ND | −1.5 | −2.4 | −2.7 |
a
Log10 of ratio of experimental condition at day 3 divided by bacterial concentration at day 1, before drug addition. A positive value denotes growth and a negative value growth inhibition or killing. Mean values of triplicate determinations are shown.
b
ND, not done.