TABLE 2.
Quinolone resistance-determining region mutations detected in ciprofloxacin-exposed P. aeruginosa isolatesa
| Isolate | Mutation
|
||
|---|---|---|---|
| GyrA | GyrB | ParE | |
| ATCC 25619 | Thr83Ile | —b | Ala473Val |
| 1 | — | Ser468Phe | — |
| 2 | Thr83Ile | — | — |
| 3 | Thr83Ile | — | Val455 insertion,c Ala473Val |
| 4 | Asp87Asn | — | — |
| 5 | Asp87His | — | Ala473Val |
| 6 | Thr83Ile | — | — |
| 7 | Asp87His | — | Ala473Val |
| 8 | Asp72Gly | Ala436Thr | — |
| 9 | Asp87Tyr | — | — |
| 10 | — | — | Ala473Val |
| 11 | Thr83Ile | — | Ala473Val |
| 12 | Thr83Ile | — | — |
| 13 | — | Ser468Tyr | — |
| 14 | Asp87Gly | — | — |
| 15 | Asp72Gly | — | — |
| 16 | Ala67Ser, Asp87Tyr | — | Pro394Arg |
| 17 | Thr83Ile | — | — |
| 18 | Thr83Ile | — | Ala473Val |
| 19 | — | Ser468Phe | — |
| 20 | — | Ser468Tyr | — |
| 21 | Thr83Ile | — | — |
| 22 | — | Glu470Asp | Not tested |
| 23 | — | Ser468 deletion | — |
| 24 | Thr83Ile | — | — |
| 25 | — | — | — |
| 26 | Asp87Gly | — | |
| 27 | — | Ser468Tyr | — |
| 28 | Asp87Tyr | — | Ala473Val |
a
No ParC quinolone resistance-determining region mutations were identified in the ciprofloxacin-exposed P. aeruginosa isolates.
b
—, no mutation identified.
c
One extra valine was present at the indicated position.