Table 2. Protein fold change in the TRIBE-AKI adult cohort and two independent validation cohorts.
All proteins are presented by names of aptamers used in the SomaScan assay. Fold change is based on the comparison of postoperative versus preoperative concentrations for the TRIBE-A KI adult cohort and pediatric cardiac surgery cohort and postrace versus prerace concentrations in the marathon cohort using paired Wilcoxon tests. P4HA2, prolyl 4-hydroxylase.
| TRIBE-AKI adult (N = 322) | Pediatric cardiac surgery (N = 68) | Marathon (N = 39) | ||||
|---|---|---|---|---|---|---|
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| Protein name | Fold change | P value | Fold change | P value | Fold change | P value |
| NLGN4X.5357.60 | 1.55 | 1.68 × 10−49 | 1.51 | 4.58 × 10−11 | 1.13 | 1.01 × 10−07 |
| COL23A1.4543.65 | 1.51 | 1.16 × 10−32 | 1.45 | 5.35 × 10−08 | 1.08 | 6.00 × 10−01 |
| TGFB2.4156.74 | 1.73 | 1.66 × 10−47 | 1.44 | 8.68 × 10−09 | 1.34 | 5.90 × 10−08 |
| CD200.5112.73 | 1.2 | 3.54 × 10−37 | 1.09 | 6.67 × 10−06 | 1.22 | 1.09 × 10−11 |
| ENPP6.15579.26 | 0.81 | 9.15 × 10−53 | 0.78 | 6.56 × 10−11 | 1.09 | 3.01 × 10−05 |
| PLG.3710.49 | 0.77 | 3.14 × 10−49 | 0.88 | 1.83 × 10−06 | 0.93 | 3.02 × 10−04 |
| PROC.2961.1 | 0.97 | 1.3 × 10−04 | 0.96 | 1.59 × 10−02 | 0.87 | 1.35 × 10−09 |
| P4HA2.11348.132 | 0.95 | 2.19 × 10−12 | 0.95 | 2.09 × 10−04 | 0.93 | 1.12 × 10−03 |
| AFM.4763.31 | 0.97 | 1.31 × 10−03 | 1.08 | 1.11 × 10−07 | 0.98 | 1.20 × 10−04 |