Table 3. Associations between postoperative markers of PT maladaptation, PT cells in healthy states, and severe AKI after cardiac surgery in patients from the TRIBE-AKI adult cohort.
All proteins are presented by names of aptamers used in the SomaScan assay, and measurements were log2-transformed so that the odds ratio represents an increase in the odds of AKI per doubling of protein concentrations.
| Odds ratio (OR, 95% CI) | Model 1* | Model 2 | Model 3 | Model 4 | Model 5 |
|---|---|---|---|---|---|
| NLGN4X.5357.60 | 1.87 (1.09–3.48) | 2.09 (1.18–4.07) | 2.48 (1.35–5.07) | 2.65 (1.37–6.1) | 6.29 (2.04–20.95) |
| COL 23A1.4543.65 | 2.04 (1.01–4.24) | 2.23 (1.08–4.74) | 2.85 (1.32–6.45) | 2.35 (1.08–5.38) | 2.54 (1.13–6.01) |
| TGFB2.4156.74 | 2.27 (1.14–4.66) | 2.53 (1.24–5.34) | 3.25 (1.5–7.4) | 2.4 (1.07–5.61) | 2.35 (1.03–5.63) |
| CD200.5112.73 | 1.94 (0.78–5) | 2.18 (0.85–5.62) | 2.42 (0.92–6.56) | 1.63 (0.54–4.46) | 3.2 (0.77–13.28) |
| ENPP6.15579.26 | 0.29 (0.05–1.09) | 0.18 (0.03–0.89) | 0.21 (0.03–0.91) | 0.29 (0.04–1.09) | 0.04 (0.003–0.39) |
| PLG.3710.49 | 0.13 (0.04–0.44) | 0.09 (0.02–0.31) | 0.12 (0.03–0.44) | 0.14 (0.03–0.54) | 0.07 (0.01–0.44) |
| PROC 2961.1 | 0.23 (0.07–0.69) | 0.15 (0.04–0.49) | 0.24 (0.06–0.88) | 0.23 (0.06–0.89) | 0.17 (0.03–0.83) |
| P4HA2.11348.132 | 0.14 (0.03–0.67) | 0.11 (0.02–0.57) | 0.18 (0.03–0.87) | 0.17 (0.03–0.84) | 0.25 (0.02–2.35) |
| AFM.4763.31 | 0.43 (0.19–1.01) | 0.42 (0.18–0.97) | 0.61 (0.25–1.52) | 0.6 (0.23–1.64) | 0.47 (0.06–3.59) |
*
Covariates were sequentially added to the regression models: Model 1 comprised postoperative markers alone; model 2 additionally adjusted for age, sex, and race; model 3 additionally adjusted for hypertension, diabetes mellitus, congestive heart failure, myocardial infarction, and baseline eGFR; model 4 additionally adjusted for baseline ACR ; model 5 additionally adjusted for preoperative marker concentrations.