TABLE 2.
Drug | Exposure concn (μg/ml) | CF releasea for lipid composition
|
|||
---|---|---|---|---|---|
PC | PC/SA (9:1) | PC/PS (9:1) | PG/CL (9:1) | ||
(+)Menthol | 100 | 0.75 | 5.7 | 0.50 | 1.56 |
250 | 4.50 | 9.40 | 5.80 | 6.70 | |
500 | 34.10 | 40.42 | 57.04 | 86.29 | |
Thymol | 100 | 1.88 | 2.17 | 1.98 | 0.18 |
250 | 12.78 | 26.67 | 9.05 | 0.39 | |
500 | 56.39 | 95.62 | 33.89 | 6.58 | |
Linalyl acetate | 100 | 0.77 | 4.80 | 1.18 | 0.66 |
250 | 6.00 | 10.25 | 13.50 | 11.25 | |
500 | 5.79 | 6.70 | 16.35 | 15.31 |
Data are expressed as the percent increase versus control of the total CF released in a 15-min period.