TABLE 2.
Results of interaction studies between citropin 1.1 and other drugsa
| Agent | FIC indexes for citropin 1.1 (range)
|
||
|---|---|---|---|
| Staphylococcus aureus | Enterococcus faecalis | Streptococcus pyogenes | |
| AMX/CLV | 0.917 (0.750-1.250) | 0.927 (0.750-1.250) | 1.292 (0.750-2.00) |
| Doxycycline | 0.385 (0.312-0.50) | 0.312 (0.187-0.50) | 0.385 (0.312-0.50) |
| Clarithromycin | 0.312 (0.187-0.50) | 0.312 (0.187-0.50) | 0.458 (0.312-0.50) |
| Linezolid | 1.50 (1.00-2.00) | 1.458 (1.250-2.00) | 1.50 (1.00-2.00) |
| Vancomycin | 1.167 (1.00-1.50) | 1.833 (1.50-2.00) | 1.292 (0.750-2.00) |
a
The ranges of concentrations tested were: 0.125 to 64 mg/liters for citropin 1.1 and 0.25 to 256 mg/liters for the other antimicrobial agents. AMX/CLV, amoxicillin-clavulanate.