TABLE 1.
Neutral red determination of inhibitory effects of interferon alfacon-1 against New World arenaviruses in vitroa
| Virus | Strain | Incubation period (days) | Drug characteristicb
|
|||||
|---|---|---|---|---|---|---|---|---|
| Interferon alfacon-1
|
Ribavirin
|
|||||||
| IC50 ± SD (ng/ml) | EC50 ± SD (ng/ml) | SI | IC50 ± SD (μg/ml) | EC50 ± SD (μg/ml) | SI | |||
| Amapari | Be An 70563 | 13 | >83 ± 29 | >100 | 1 | 67 ± 30 | 664 ± 291 | 0 |
| Latino | 10924 | 12 | >80 ± 35 | >100 | 1 | 110 ± 63 | 260 ± 143 | 0 |
| Pichinde | An 4763 | 7 | >98 ± 4 | 2.0 ± 0.3 | >49 | 376 ± 209 | 37 ± 10 | 10 |
| Tacaribe | TRVL 11573 | 10 | >100 | 0.4 ± 0.3 | >250 | 110 ± 51 | 9 ± 5 | 12 |
| Tamiami | W-10777 | 13 | >100 | >100 | 1 | 90 ± 47 | 405 ± 138 | 0 |
a
Data are the means and standard deviations from three or four independent NR experiments.
b
SI, calculated as IC50/EC50, is the selectivity (therapeutic) index.