TABLE 2.
Effect of intraperitoneal interferon alfacon-1 treatmenta on hamsters challenged with Pichinde virus
| Drug | Dosage (mg/kg/day) | No. of survivors/total | Mean day of deathb ± SD | Mean virus titer ± SD
|
Mean serum ALTef (IU/liter) ± SD | |
|---|---|---|---|---|---|---|
| Liverc | Serumd | |||||
| Interferon alfacon-1 | 0.01 | 8/10*** | 12.5 ± 2.1* | 4.6 ± 0.1** | 4.6 ± 0.1** | 24 ± 18** |
| Interferon alfacon-1 | 0.001 | 4/10** | 9.5 ± 1.0* | 7.8 ± 0.5* | 6.7 ± 0.9* | 65 ± 33** |
| Ribavirin | 40 | 10/10*** | 4.5 ± 0.0** | 4.8 ± 0.5** | 24 ± 15** | |
| Saline | 0/20 | 8.2 ± 0.8 | 9.0 ± 0.4 | 8.6 ± 0.8 | 294 ± 127 | |
a
Once daily for 7 days beginning 4 h pre-virus inoculation (ribavirin administered twice daily). *indicates a P of <0.05, **indicates a P of <0.01, and *** indicates a P of <0.001 in comparison to saline-treated controls.
b
Mean day of death of hamsters dying prior to day 21.
c
log10 cell culture 50% infectious dose/g.
d
log10 cell culture 50% infectious dose/ml.
e
ALT, alanine aminotransferase; measured in international units per liter.
f
ALT and virus titers were determined for five hamsters/group sacrificed on day 6.