TABLE 4.

Effect of intraperitoneal poly(I:C₁₂U) treatment on hamsters challenged with Pichinde virus

Drug	Dosage (mg/kg/day)/ start of treatment (h)	No. of survivors/total	Mean day of deathc ± SD	Mean virus titer ± SD		Mean serum ALTfg (IU/liter) ± SD
				Liverd	Serume
Experiment 1
poly(I:C12U)a	4/−4	0/10	11.0 ± 4.0	7.9 ± 0.9	7.3 ± 1.5	233 ± 164
	4/24	0/10	9.6 ± 1.6	7.4 ± 1.3	6.9 ± 1.0*	240 ± 67
	1/−4	3/10*	10.3 ± 2.2*	6.9 ± 0.8*	6.6 ± 1.2*	89 ± 40
	1/24	0/10	9.7 ± 3.4	8.5 ± 0.3	8.2 ± 0.6	434 ± 217
Ribavirin	40/−4	10/10***		4.7 ± 1.2**	4.7 ± 1.2**	34 ± 25
Salinea	/−4	0/20	9.0 ± 2.3	8.3 ± 0.5	8.2 ± 0.4	139 ± 25
Sham-infected		3/3***				60 ± 43
Experiment 2
poly(I:C12U)a	1/−24	1/10	11.0 ± 0.8	7.4 ± 0.7	6.1 ± 1.5	85 ± 24*
	0.25/−24	3/10*	10.1 ± 0.4	7.2 ± 1.6	6.9 ± 1.7	159 ± 55
	1/−48	0/10	11.5 ± 1.2*	7.8 ± 1.0	6.3 ± 1.2	182 ± 40
	0.25/−48	1/10	11.7 ± 1.4*	8.2 ± 1.3	6.6 ± 2.0	551 ± 238
Ribavirin	40/−4	10/10***		4.5 ± 0.0**	3.7 ± 0.1**	80 ± 22*
Salinea	/−24	0/20	10.5 ± 0.9	8.2 ± 0.7	6.6 ± 0.8	258 ± 68
Sham-infected		3/3***				35 ± 7*
Experiment 3
poly(I:C12U)b	1/−24	2/10	10.6 ± 1.8	6.1 ± 1.7	5.2 ± 1.5	854 ± 1,031
	0.1/−24	2/10	10.5 ± 1.4*	5.5 ± 1.0	4.3 ± 1.2	707 ± 792
Ribavirin	40/−4	10/10***		4.7 ± 0.3	3.5 ± 0.0	43 ± 25**
Salineb	/−24	0/20	9.5 ± 1.1	5.2 ± 1.4	4.4 ± 1.3	1,528 ± 302
Sham-infected		4/4***				38 ± 11*

^aSingle dose; 50-g hamsters.

^bTreatment every 4 days (−1, 3, and 7); 100-g hamsters.

^cMean day to death of hamsters dying prior to day 21.

^dlog₁₀ cell culture 50% infectious dose/g.

^elog₁₀ cell culture 50% infectious dose/ml.

^fALT, alanine aminotransferase, is measured in international units per liter.

^gALT and virus titers were determined for five hamsters/group sacrificed on day 6 for experiments 1 and 2 and on day 7 for experiment 3.