TABLE 4.

Matrix of correlation coefficients (r²) between drug responses^a

Study phase	Drug	r2 value for drug responses
		CQ	DOX	AQ	AS	DHA	LUM	MFQ	QN
Phase I	CQ		0.003	0.016	0.001	0.014	0.014	0.005	0.027
	DOX	55		0.007	0.006	0	0.008	0.011	0.016
	AQ	57	49		0.097	0.1	0.079	0.047	0.02
	AS	67	54	56		0.728	0.27	0.267	0.219
	DHA	69	56	57	74		0.297	0.22	0.16
	LUM	63	48	50	63	63		0.559	0.355
	MFQ	80	55	65	73	76	66		0.506
	QN	80	59	65	76	78	66	94
Phase II	CQ		0.03	0.075	0.002	0.035	0.048	0.013	0.015
	DOX	161		0.033	0.001	0.051	0.037	0	0
	AQ	175	158		0.008	0.018	0.023	0.006	0
	AS	151	135	152		0.383	0.16	0.334	0.152
	DHA	164	145	163	152		0.227	0.216	0.169
	LUM	157	139	149	141	147		0.51	0.318
	MFQ	186	162	178	156	169	163		0.554
	QN	161	164	154	133	145	140	164

^aSignificance of correlations is indicated: bold, P < 0.0001; italic bold, P < 0.001; underline, P < 0.01. Correlations were performed on log-transformed IC₅₀ data.