TABLE 3.
Comparison of resistant rates with Haemophilus influenzae during five study periods between 1994-1995 and 2002-2003
| Antimicrobial agent or resistance factor | Percentage resistant in
|
||||
|---|---|---|---|---|---|
| 1994-1995a | 1997-1998b | 1999-2000c | 2000-2001d | 2002-2003e | |
| β-Lactamase positive | 36.4 | 31.1 | 30.8 | 28.9 | 26.2 |
| BLNARf | 1.3 | 1.9 | 2.0 | 0.7 | 0.1 |
| BLPACRg | 3.0 | 2.0 | 0.2 | 0.7 | 0.4 |
| Ampicillin | 36.6 | 32.4 | 34.6 | 29.4 | 26.3 |
| Amoxicillin-clavulanate | 5.0 | 2.4 | 0.3 | 0.5 | 0.1 |
| Cefprodoxime | 0.1 | 0.0 | 0.1 | 0.1 | 0.0 |
| Cefuroxime | 1.5 | 1.0 | 1.1 | 0.5 | 0.1 |
| Clarithromycin | 1.8 | 4.2 | 6.8 | 6.3 | 1.7 |
| Azithromycin | 0.5 | 1.9 | 2.9 | 2.4 | 1.0 |
| TMP-SMX | 9.0 | 18.3 | 14.6 | 17.6 | 14.6 |
| Chloramphenicol | 0.5 | 0.5 | 0.5 | 0.6 | 0.4 |
| Tetracycline | 1.3 | 1.0 | 0.7 | 1.1 | 0.4 |
a
1537 isolates from 34 centers (5)
b
1529 isolates from 34 centers (data on file)
c
1354 isolates from 33 centers (data on file)
d
1025 isolates from 45 centers (data on file)
e
986 isolates from 45 centers (current study)
f
BLNAR, percentage of β-lactamase negative isolates that were resistant to ampicillin.
g
BLPACR, percentage of β-lactamase positive isolates that were resistant to amoxicillin-clavulanate.