Table 3.
The DSC thermograms were used to derive the thermodynamic parameters for apo Ha006a and Ha006a-ligand complexes.
| Tm (°C) ± SE | ΔH (kcal/mol) | ΔHv (kcal/mol) | ΔHv/ΔH | |
|---|---|---|---|---|
| Apo Ha006a | Tm1 48.13 ± 0.49 | 2.49E+05 | 5.29E+04 | 0.21 |
| Tm2 73.13 ± 0.18 | 3.41E+06 | 4.13E+04 | 0.01 | |
| Tm3 90.06 ± 0.17 | 2.21E+06 | 5.33E+04 | 0.02 | |
| Donepezil | Tm1 50.12 ± 0.45 | 1.17E+05 | 4.71E+04 | 0.40 |
| Tm2 63.42 ± 0.62 | 2.08E+05 | 3.51E+04 | 0.17 | |
| Tm3 82.46 ± 0.79 | 1.24E+05 | 3.52E+04 | 0.28 | |
| Protopine | Tm1 49.93 ± 0.55 | 6.30E+05 | 4.32E+04 | 0.07 |
| Tm2 66.76 ± 0.33 | 1.87E+06 | 3.15E+04 | 0.02 | |
| Tm3 86.29 ± 0.67 | 7.83E+05 | 4.01E+04 | 0.05 | |
| 3′,4′,5,7-Tetramethoxyflavone | Tm1 51.52 ± 0.25 | 5.84E+05 | 3.40E+04 | 0.06 |
| Tm2 79.01 ± 0.98 | 9.57E+05 | 3.53E+04 | 0.04 | |
| Tm3 91.76 ± 0.43 | 3.58E+05 | 5.88E+04 | 0.16 | |
| Piperine | Tm1 51.30 ± 0.32 | 2.18E+05 | 4.33E+04 | 0.20 |
| Tm2 65.47 ± 0.33 | 2.09E+05 | 4.08E+04 | 0.20 | |
| Tm3 80.80 ± 0.36 | 4.46E+04 | 4.09E+04 | 0.92 | |
| Triphenyl phosphate | Tm1 51.32 ± 1.70 | 4.57E+05 | 3.59E+04 | 0.08 |
| Tm2 67.66 ± 0.26 | 1.31E+06 | 6.68E+04 | 0.05 | |
| Tm3 78.21 ± 0.44 | 4.72E+05 | 8.95E+04 | 0.19 |
The displayed values include van’t Hoff enthalpy ΔHv (kcal/mol), molar heat enthalpy ΔH (kcal/mol) and the ΔHv/ΔH ratio. Additionally, the table presents the thermal transition temperature (Tm) in the form of molar heat capacity.