Table 2.
Characteristics of the study population and associations with overall survival.
| Characteristics at diagnosis | Subgroup | N | % | Age- and stage-adjusted HR (95% CI) |
|---|---|---|---|---|
| Age (mean & range) | 5724 | 57.1 (20–87) | ||
| Vital status | Alive | 2295 | 40.1 | |
| Deceased | 3429 | 59.9 | ||
| Year of diagnosis | 1992-9 | 974 | 17.0 | 1.00 |
| 2000-3 | 1109 | 19.4 | 0.77 (0.67–0.89) | |
| 2003-6 | 2083 | 36.4 | 0.76 (0.66–0.87) | |
| 2006-9 | 761 | 13.3 | 0.75 (0.64–0.88) | |
| 2012-5 | 797 | 13.9 | 0.68 (0.50–0.93) | |
| Age group | < 40 | 346 | 6.0 | 0.58 (0.48–0.70) |
| 40–49 | 1058 | 18.5 | 0.79 (0.71–0.88) | |
| 50–59 | 1858 | 32.5 | 1.00 (Ref) | |
| 60–69 | 1676 | 29.3 | 1.15 (1.06–1.25) | |
| 70+ | 786 | 13.7 | 1.42 (1.28–1.57) | |
| Tumour stage | Local | 1122 | 19.6 | 1.00 |
| Regional | 939 | 16.4 | 1.64 (1.39–1.94) | |
| Distant | 3488 | 60.9 | 6.05 (5.31–6.90) | |
| Missing | 175 | 3.1 | ||
| Histotype | High grade serous | 3436 | 60.0 | 1.00 |
| Low grade serous | 179 | 3.1 | 0.66 (0.54–0.80) | |
| Mucinous | 313 | 5.5 | 0.61 (0.49–0.76) | |
| Endometrioid | 844 | 14.7 | 0.54 (0.47–0.62) | |
| Clear cell | 377 | 6.6 | 0.74 (0.62–0.89) | |
| Mixed/Other | 575 | 10.0 | 0.88 (0.78–0.99) | |
| Residual disease after surgerya | Nil | 1088 | 19.0 | 1.00 |
| Any | 878 | 15.3 | 1.94 (1.70–2.21) | |
| Missing | 3758 | 65.7 | ||
| Menopausal statusb | Pre- and perimenopause | 1543 | 27.0 | 1.00 |
| Post menopause | 4045 | 70.7 | 1.09 (0.97–1.23) | |
| Missing | 136 | 2.4 | ||
| Menopausal hormone | No | 3760 | 65.7 | 1.00 |
| use | Yes | 1856 | 32.4 | 0.92 (0.85–0.99) |
| Missing | 108 | 1.9 | ||
| Race/Ethnicity | Non-Hispanic White | 4852 | 84.8 | 1.00 |
| Hispanic | 141 | 2.5 | 0.92 (0.72–1.18) | |
| Black | 64 | 1.1 | 1.11 (0.76–1.63) | |
| Asian | 393 | 6.9 | 0.97 (0.83–1.14) | |
| Other | 274 | 4.8 | 1.06 (0.90–1.26) | |
| Education | Less than high school | 1055 | 18.4 | 1.00 |
| High school | 2836 | 49.6 | 1.01 (0.92–1.11) | |
| College or University | 1784 | 31.2 | 0.94 (0.85–1.05) | |
| Missing | 49 | 0.9 | ||
| Smoking status | Never smoker | 3097 | 54.1 | 1.00 |
| Former smoker | 1842 | 32.2 | 1.13 (1.05–1.22) | |
| Current smoker | 743 | 13.0 | 1.25 (1.13–1.39) | |
| Missing | 42 | 0.7 | ||
| Body Mass Index | <25.0 | 2762 | 48.3 | 1.00 |
| (kg/m2) | ≥ 25 to < 30 | 1668 | 29.1 | 0.93 (0.86–1.01) |
| ≥ 30 | 1243 | 21.7 | 1.12 (1.03–1.22) | |
| Missing | 51 | 0.9 | ||
| Physical activityc | Inactive | 1255 | 21.9 | 1.00 |
| Active | 3986 | 69.6 | 0.93 (0.85–1.01) | |
| Missing | 483 | 8.4 |
CI confidence interval, HR hazard ratio, adjusted for age and stratified by site.
aResidual disease information was not available for DOV, LAC, MCC, NJO or POL.
bMenopausal status data were not available for MCC.
cPhysical inactivity data were not available for MCC or POL.