Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Sep 16;81(1):405. doi: 10.1007/s00018-024-05430-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

PMC Copyright notice

Fig. 3 — Deficiency of C3 protects against severe COVID-19 in K18-hACE2 transgenic mice infected with an original SARS-CoV2 strain. A–C C3 deficient and sufficient mice expressing hACE2 under the control of the K18 promoter (C3^−/−/K18-hACE2^+/− and C3^+/+/K18-hACE2^+/−) aged 15 weeks with mixed-sex were infected with SARS-CoV-2-WA1 strain (n = 9/group, 5 females and 4 males per group) with 4 mice/group euthanized at 4 DPI and the others at 7 DPI. A Percent body weight changes. p-value = 0.0036 by two-way ANOVA, and B viral load of lung by qPCR showing no significance after infection. C Hemolytic activity of the infected C3^−/−/K18-hACE2^+/− and C3^+/+/K18-hACE2^+/− at 3 and 7 DPI using 8% diluted serum as the source of complement