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. 2024 Sep 16;15:8090. doi: 10.1038/s41467-024-52485-1

Fig. 1. Screening for TadA orthologs with cytosine deaminase activity in mammalian cells.

Fig. 1

a The experimental workflow for detecting base editing activity with fluorescence reporter system in HEK293T cells. b The Phylogenetic Tree of TadA orthologs. c Screening for TadA orthologs using fluorescence reporter system. Data are presented as means ± S.D. Values and error bars represent mean and S.D., n = 3 independent biological replicates. All of the above base editors do not contain UGI. PAM stands for protospacer adjacent motif. NC represents negative control. Source data are provided as a Source Data file.