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. 2024 Sep 16;15:8129. doi: 10.1038/s41467-024-52233-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — A Principal component analysis of the four sample groups (WT - OP50, WT - PA14, skn-1gf - OP50, and skn-1gf - PA14) indicates unique and context-dependent transcriptional responses. B Analyses of the various classes of genes with unique transcriptional responses revealed similarities upon pairwise comparisons and three-way comparisons, along with identifying 1348 genes that are differentially expressed across comparisons. C Genotype-specific responses to PA14 identified 363 genes with reversed directionality of transcriptional response between WT and skn-1gf animals (170 down-regulated and 193 up-regulated in WT in comparison to skn-1gf). 579 genes with similar directionality but the differential magnitude of the transcriptional response between WT and skn-1gf mutants (322 down-regulated and 257 up-regulated). RNAseq data is available at the NIH (GEO) Gene Expression Omnibus (GSE251677). Source data for all Genotype-specific transcriptional responses are provided as a Source Data file 3.