Fig. 5. Risk factors for overall survival (OS) in 225 patients with t-AML.

A Univariate Cox regression shows hazard ratio defined as risk of death from several risk factors in t-AML. Factors that were mainly determined by the previous disease are depicted in turquoise letters. B Multivariate Cox regression shows HR defined as risk of death from factors with univariate significance in t-AML and reveals ECOG-PS > 1, an adverse cytogenetic/molecular risk according to the ELN 2010 classification, intensive therapy, BMI < 18.5 kg/m² and diabetes mellitus as independent risk factors for OS in t-AML (depicted in orange letters). WBC white blood cell count, Hb hemoglobin, PLT platelets, CCI Charlson comorbidity index, ECOG Eastern Cooperative Oncology Group, BMI body-mass index, ELN European LeukemiaNet, HR hazard ratio, CI confidence interval.