TABLE 1.

Tumor growth rates on day 21^a

Treatment	Mean tumor vol (mm3) ± SE	Growth rate (mm3/day)	% Growth inhibition
Stat3Y705-F	101.1 ± 39.09*	7.55 ± 1.15*	57.14,b 63.84c
pRc/CMV	235.9 ± 52.55†	16.52 ± 1.287†
Wild-type C4HD	279.6 ± 49.15†	18.92 ± 1.597†

^aAll experimental protocols were performed with mice treated with a 40-mg s.c. MPA depot in the flank opposite the cell inoculum. Mice were inoculated with C4HD cells transfected with either the DN Stat3Y705-F expression vector or the empty pRc/CMV vector and with wild-type C4HD cells. While control groups contained nine mice each, only four of the nine mice injected with cells transfected with the DN Stat3Y705-F vector developed tumors. Growth rate was calculated as the slopes of growth curves. At day 21, tumor volume and percentage of growth inhibition in tumors from mice injected with cells transfected with the DN Stat3Y705-F expression vector with respect to mice injected with the empty pRc/CMV vector or with wild-type C4HD cells were calculated as described in Materials and Methods. * versus †, P < 0.001.

^bWith respect to pRc/CMV treatment.

^cWith respect to wild-type C4HD treatment.