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. 2024 May 17;18:322–339. doi: 10.1016/j.aninu.2024.05.001

Fig. 2.

Fig. 2

The sources and absorption of SCFA. The sources of SCFA in body includes exogenous intake from food, such as milk, and endogenous biosynthesis of non-digestible carbohydrates by gut microbiota in the cecum and colon. The transporters including SLC5A8, MCT1 and the receptors including GPR41 (FFAR3), GPR43 (FFAR2), and GPR109A are involved in the absorption of SCFA in the intestine. The absorbed SCFA enter the portal vein, and then dispersed to peripheral tissues, including brain, kidney, liver, lung, bone and cardiovascular tissues. SCFA = short chain fatty acids; SLC5A8 = solute carrier family 5 member 8; MCT1 = monocarboxylate transporter 1; GPR41 = G-protein coupled receptor 41; GPR43 = G-protein coupled receptor 43; GPR109A = G-protein coupled receptor 109A; FFAR2 = free fatty acid receptor 2; FFAR3 = free fatty acid receptor 3.