Figure 5.

PI3K inhibition ameliorates PQ-induced inflammatory damages in the BBB and brain tissues. Rats were administrated with PQ for 3 weeks in the presence or absence of PI3K inhibitor or treated with PIK3 inhibitor alone. (a) Evans blue dye penetration analysis and quantification in each group. (b) H&E staining of the brain tissues. (c) ELISA analysis of inflammatory cytokine IL-6 in the blood samples. (d) Detection of ROS levels in the brain tissues. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.