Fig. 3.

Time dependence of the number of phosphorylated TCR residues when forces act directly on the TCR–pMHC bond (A–C) and for finite TCR rigidities. Parameter values are $f_{\omega }=5$ pN, $a/k_{B}T=1$ pN⁻¹, $k_{\text{off,0}}=k_p=k_{\mathit{dp}}=1$ s⁻¹, and $n_{p,\text{max}}=20$ as well as $f_0=12.5$ pN and $f_c=25$ pN (A and D), $f_0=2.5$ pN and $f_c=25$ pN (B and E), and $f_0=7.5$ pN and $f_c=15$ pN (C and F). In (D–F), additionally, $k_{\text{MHC}}=5$ pN/nm, $\mathrm{\Delta }=1$ nm, ${\xi }_{\text{TCR}}={\xi }_{\text{TCR}}=5$ pN/(nm/s).