TABLE 1.
Clinical and postmortem characteristics of the analytic cohort
| Variable | No Dementia n=175 |
Dementia* n=125 |
||
|---|---|---|---|---|
| mean or n | SD or % | mean or n | SD or % | |
| Age at study baseline | 82.17 | 5.81 | 82.77 | 5.39 |
| Age at death | 90.73 | 6.08 | 91.27 | 6.27 |
| Years of education | 14.94 | 2.91 | 14.55 | 3.12 |
| Female sex | n=123 | 70% | n=90 | 72% |
| History of head injury | n=73 | 42% | n=46 | 37% |
| Number of illnesses last visit (0,7) | 0.61 | 0.92 | 0.36 | 0.59 |
| APOE4 genotype | n=25 | 14% | n=49 | 39%^ |
| Final cognitive status no cognitive impairment | n=107 | 61% | - | - |
| Final cognitive status mild cognitive impairment | n=68 | 39% | - | - |
| Global cognition at baseline | 0.17 | 0.51 | −0.50 | 0.81^ |
| Global cognition at last visit | −0.17 | 0.58 | −2.16 | 0.92^ |
| Minimental Status Exam at baseline (0-30) | 28.0 | 1.68 | 25.12 | 5.53^ |
| Minimental Status Exam at last visit (0-30) | 26.7 | 2.57 | 11.29 | 8.42^ |
| Time from last cognitive exam to death (months)** | 9.6 | 6.5,14.0 | 6.2 | 3.8,10.1^ |
| Postmortem interval (hours) | 9.64 | 9.28 | 8.75 | 4.57 |
| # Tau-tangles density | 5.15 | 5.08 | 14.50 | 12.19^ |
| # Aβ burden | 3.75 | 3.79 | 5.40 | 3.79^ |
| Global AD pathology score | 0.62 | 0.54 | 1.09 | 0.67^ |
| CERAD (Yes, definite/probable) | n=107 | 61% | n=109 | 87%^ |
| ADNC (pathologic diagnosis of AD) | n=104 | 50% | n=103 | 82%^ |
*
t-test or Chi-square significance <0.001
**
median, interquartile range (IQR)
#
Aβ and tau-tangles indices collected from 8 sites within the cerebrum as described in the methods