Table 1. Comparison of the plasma parameters between the groups.

Biochemical parameters	x̄ ± SD (min.–max.)				Test value	P-value
	Group 1 (a)	Group 2 (b)	Group 3 (c)	Group 4 (d)
EGF (ng/l)	43.95 ± 51.46 (1.55–105.97)	77.37 ± 71.95 (142–198.75)	53.15 ± 54.37 (0.85–134.85)	4.29 ± 2.34 (1.88–9.14)	3.489	0.025
	b > d, c > d, a = b = c, a = d*
MCP-1 (pg/ml)	16.38 ± 12.71 (1.05–40.16)	208.31 ± 75.96 (10.32–324.87)	229.12 ± 44.14 (165.66–328.58)	203.53 ± 74.89 (5.41–271.16)	20.939	0.000
	b = c = d > a*
BFGF (pg/ml)	56.82 ± 14.95 (39.41–83.55)	53.13 ± 14.84 (31.67–87.87)	43.89 ± 18.35 (0.22–74.90)	56.50 ± 11.96 (38.34–71.02)	1.647	0.195
IL-8 (ng/l)	47.66 ± 20.46 (2.45–63.18)	43.08 ± 6.29 (32.00–52.91)	41.53 ± 5.37 (32.33–48.71)	40.89 ± 6.83 (30.40–48.56)	0.743	0.533
COL-1 (ng/l)	336.58 ± 43.34) (307.67–400.31)	362.83 ± 44.72 (323.45–488.92)	341.06 ± 48.24 (276.42–410.14)	353.08 ± 26.17 (312.88–389.18)	0.673	0.575

*Statistical differences

BFGF = basic fibroblast growth factor; COL-1 = collagen-1; EGF = epidermal growth factor; IL-8 = interleukin-8; MCP-1 = monocyte chemoattractant protein-1