Table 2. Antiplasmodial Activity of SQ109 Analogs with Changes around the Ethylenediamine Linker.

^aHepG2 viability as a % inhibition when treated with compound at 20 μM.

^bPublished in Stampolaki et al.⁵ All cell growth inhibition data are from ≥2 independent biological repeats, each performed in technical duplicates, mean ± SE indicated. WlogP was predicted using the free web tool, SwissADME²⁰ and log D_7.4 was computed using Chemicalize (https://chemicalize.com). nd = not determined.