Table 3. Antiplasmodial Activity of SQ109 Analogs with Changes around the Geranyl Tail.

^aHepG2 viability as a % inhibition when treated with compound at 20 μM. All cell growth inhibition data are from ≥2 independent biological repeats, each performed in technical duplicates, mean ± SE indicated. W log P was predicted using the free web tool, SwissADME²⁰ and log D_7.4 was computed using Chemicalize (htpps://chemicalize.com). nd = not determined.