Figure 6.
BRF1A suppressed the expression of targets critical for the survival and function of IgE-producing myeloma cells (U266 cells). U266 cells were cultured with BRF1A at a concentration of 1 µM for 24 hours. Western blot assay was conducted as described in the section “Materials and Methods”. (A) Western bands (B) NFκB. (C) p-NFκB. (D) p-IκBα. (E) XBP1u. (F) XBP1s.
Data represent triplicate experiments and are expressed as mean ± SD. *P < .05; **P < .01, ***P < .001 versus control (0.1% DMSO).