| miR-203 |
upregulated |
PDAC cells |
dendritic cells |
It can downregulate TLR4 in dendritic
cells and subsequently
reduce TNF-α and IL12 release by dendritic cells. |
(72) |
| miR-146a |
upregulated |
PDAC cells |
dendritic cells |
It inhibited phenotypic differentiation
and maturation of dendritic
cells by decreasing the expression of CD80, CD86, CD1a, HLA-DR, and
CD83. |
(74) |
| miR-212-3p |
upregulated |
PDAC cells |
dendritic cells |
By downregulating
RFXAP, it decreases MHC II transcription
in dendritic cells. |
(75) |
| miR-128 |
downregulated |
PDAC cells |
dendritic cells,
PDAC cells |
It enhances the expression of MHC I, MHC
II, and costimulatory
molecules, CD80 and CD86, in dendritic cells. It also downregulates
CD47 in PDAC cells by targeting ZEB1, thereby attenuating the defense
mechanism of tumor cells against recognition by immune cells. |
(77) |
| miR-183-5p |
NA |
PDAC cells |
macrophages |
It induces the M1 polarization of
macrophages. |
(80) |
| miR-301a |
upregulated |
PDAC cells |
macrophages |
By attenuating
the inhibitory effect of PTEN on PI3K/Akt/mTORC1
pathway, it promotes M2 polarization of macrophages. |
(53) |
| miRNA-320a |
upregulated |
CAFs |
macrophages |
By attenuating the inhibitory effect
of PTEN on the PI3K/AKT/mTORC1
pathway, it promotes M2 polarization of macrophages. |
(33) |
| miR-340 |
downregulated |
PDAC cells |
PDAC cells |
It downregulates CD47 on cancer cells
and inhibits CD47-SIRP-α
interaction, thereby accelerating tumor cell phagocytosis. |
(84) |
| miR-125b |
NA |
|
M2 macrophages |
It reprograms M2 macrophages to show
M1 features. |
(86) |
| miR-21-5p |
upregulated |
M2 macrophage |
PDAC cells |
It inhibits
KLF3 in PDAC cells, thereby promoting their proliferation. |
(82) |
| miR-501-3p |
upregulated |
M2
macrophage |
PDAC cells |
Targeting the 3′-UTR
of TGFβR3 in cancer cells
and promoting their EMT and angiogenesis. |
(83) |
| miR-122-5p |
downregulated |
PDAC cells |
PDAC cells |
By inhibiting XIAP, it induces apoptosis
in PDAC cells. |
(89) |
| lncRNA SBF2-AS1 |
upregulated |
M2 macrophage |
PDAC cells |
It attenuates the inhibitory effect of miR-122-5p on XIAP,
thereby preventing PDAC cell apoptosis. |
(89) |
| miR-365 |
upregulated |
M2 macrophage |
PDAC cells |
It induces resistance to gemcitabine
in PDAC cells. |
(91) |
| miR-222-3p |
upregulated |
M2 macrophage |
PDAC cells |
It induces
resistance to gemcitabine in PDAC cells. |
(92) |
| miR-153 |
downregulated |
PDAC cells |
PDAC cells |
It targets the 3′-UTR of HIF-1α
and ADAM10 in
PDAC cells, thereby upregulating MICA and MICB in PDAC cells and NKG2D
in neighboring NK cells. |
(21) |
| circ_0000977 |
upregulated |
PDAC cells |
PDAC cells |
By inhibiting miR-153, it downregulates MICA and MICB in PDAC
cells and NKG2D in neighboring NK cells. |
(21) |
| miR-4299 |
downregulated |
PDAC cells |
PDAC cells |
It markedly downregulates ADAM17 in
PDAC cells and upregulates
NKG2D in NK cells. |
(94) |
| miR-3607-3p |
downregulated |
NK cells |
PDAC cells |
By targeting IL26, it suppressed the proliferation, migration,
and invasion of cancer cells. |
(99) |
| lncRNA AL137789.1 |
upregulated |
PDAC cells |
CD8+ cells |
It inhibits CD8+ cytotoxicity against
PDAC cells. |
(27) |
| miR-148a-3p |
downregulated |
PDAC cells |
PDAC cells |
It increases
the abundance of CD8+ T cells and CD4+ T cells
and decreases the abundance of T Reg cells by downregulating PD-L1. |
(106) |
| hsa_circ_0046523 |
upregulated |
PDAC cells |
PDAC cells |
By inhibiting
miR-148a-3p, it upregulates PD-L1, thereby decreasing
the abundance of CD8+ T cells and CD4+ T cells and increasing the
abundance of T Reg. |
(106) |
| miR-142-5p |
NA |
PDAC cells |
PDAC cells |
By targeting the 3′-UTR of PD-L1, it promotes tissue
infiltration of CD4+ and CD8+ T cells, reduces the expression of PD-L1
and the population of PD-1-positive tumor-infiltrating lymphocytes,
and enhances the expression of INF-γ and TNF-α |
(107) |
| miR-519 |
downregulated |
PDAC cells |
PDAC cells |
By targeting the
3′-UTR of PD-L1, it promotes T cell
cytotoxicity against cancer cells. |
(109) |
| miR-194-5p |
downregulated |
PDAC cells |
PDAC cells |
It promotes CD8+ T cell infiltration
and increases the release
of IL2, INF-γ, and granzyme B by T cells by targeting the 3′-UTR
of PD-L1 and decreasing its expression in cancer cells. |
(108) |
| miR-155-5p |
upregulated |
PDAC cells |
PDAC cells |
It upregulates immune checkpoint proteins
such as FAS and PD-L1,
thereby decreasing the tissue abundance of T cells and increasing
the tissue abundance of M2 macrophages and MDSCs. It also upregulates
CD47. |
(110) |
| miR-503-5p |
downregulated |
PDAC cells |
PDAC cells |
It inhibits
anilin expression, thereby improving CD8+ T cell
response and promotes the M1 polarization of macrophages. |
(112) |
| lncRNA LINC00460 |
upregulated |
PDAC
cells |
PDAC cells |
By sponging miR-503-5p,
it suppresses CD8+ T cell response
and promoting M2 polarization of macrophages. |
(112) |
| miR-195-5p |
downregulated |
PDAC cells |
PDAC cells |
By targeting the 3′-UTR of
PD-L1, it enhances CD8+ T
cell response. |
(117) |
| LINC00473 |
upregulated |
PDAC cells |
PDAC cells |
It inhibits
miR-195-5p and suppresses CD8+ T cell response. |
(117) |
| let-7c-5p |
NA |
PDAC cells |
CD8+ cells |
It suppresses IL2 and INF-γ production
by T cells. |
(118) |
| miR-382-3p |
downregulated |
PDAC cells |
PDAC cells |
By sponging
STAT-1, it inhibits PD-L1 expression and promotes
CD8+ cytotoxicity. |
(22) |
| lncRNA PSMB8-AS1 |
upregulated |
PDAC cells |
PDAC cells |
It inhibits miR-382-3p, thereby upregulating PD-L1 expression
and promoting CD8+ cytotoxicity. |
(22) |
| circPTPN22 |
upregulated |
PDAC cells |
PDAC cells |
By upregulating STAT-3, it hinders
tissue infiltration of CD8+
T cells, CD4+ T cell, γδ T cell, and NK cell, and reduces
INF-γ and granzyme B production by CD8+ T cells
|
(119) |
| circMYO1C |
upregulated |
PDAC cells |
PDAC cells |
It upregulates
PD-L1 and weakens CD8+ cytotoxicity. |
(124) |
