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Roles of OGT in cancer metabolism
| Molecular pathway | Function | References |
|---|---|---|
| OGT/PGK1 | Promotes the glycolysis and growth; Inhibit mitochondrial TCA cycle | [93] |
| OGT/PKM2 | Promotes the aerobic glycolysis and growth | [94] |
| OGT/IDH2 | Promotes the proliferation and lactic acid production; Reduces ROS production | [95] |
| OGT/SREBP-1 | Promotes the cell survival and lipid synthesis | [99] |
| OGT/CDK5 | Regulates acetate metabolism | [102] |
