Table 1.
Bilateral, right and left unilateral distribution of colorectal liver metastases and vascular anatomy
| Characteristics | Overall, N = 200a | Bilateral N =110 (55%)a | Right unilateral N = 66 (33%)a | Left unilateral N = 24 (12%)a | P-valueb |
|---|---|---|---|---|---|
| Patient | |||||
| Age (years) | 64 (57–71) | 63 (53–70) | 65 (58–74) | 67 (63–71) | 0.02 |
| Gender: female | 81 (41) | 47 (43) | 29 (44) | 5 (21) | 0.11 |
| BMI (kg/m2) | 24 (21.0–27.0) | 24 (21.0–27.0) | 24 (22.0–26.0) | 24 (23.0–27.3) | 0.70 |
| Primitive tumor location | 0.60 | ||||
| Right colon | 34 (17) | 16 (15) | 12 (18) | 6 (25) | |
| Left colon | 112 (57) | 60 (56) | 38 (58) | 14 (58) | |
| Rectum | 52 (26) | 32 (30) | 16 (24) | 4 (17) | |
| T stage | 0.60 | ||||
| 0–2 | 31 (18) | 15 (17) | 10 (17) | 6 (26) | |
| 3–4 | 139 (82) | 74 (83) | 48 (83) | 17 (74) | |
| N stage | 0.80 | ||||
| 0 | 66 (40) | 33 (38) | 23 (43) | 10 (43) | |
| 1–2 | 98 (60) | 55 (63) | 30 (57) | 13 (57) | |
| KRAS mutation | 60 (30) | 33 (30) | 20 (30) | 7 (29) | > 0.90 |
| BRAF mutation | 6 (3) | 4 (3.6) | 2 (3) | 0 (0) | > 0.90 |
| MSI | 4 (2) | 2 (1.8) | 1 (1.5) | 1 (4.2) | 0.60 |
| Number of CRLM | 3 (1–7) | 6 (4–11) | 1 (1–3) | 1 (1–1) | < 0.01 |
| Synchronous CRLM | 140 (70) | 87 (79) | 38 (58) | 15 (63) | 0.01 |
| Vascular | |||||
| PV variations | 0.13 | ||||
| Type 1 | 156 (78) | 88 (80) | 51 (77) | 17 (71) | |
| Type 2 | 19 (9,5) | 13 (12) | 3 (4.5) | 3 (13) | |
| Type 3 | 25 (13) | 9 (8.2) | 12 (18) | 4 (17) | |
| PV diameter | |||||
| Main trunk | 13.5 (12.4–15) | 13.3 (12.4–15) | 13.7 (12.50–15) | 13.8 (12.15–14.20 | > |
| RPV | 11.3 (10.0–12.9) | 11.4 (10.0–13.0) | 11.3 (10.0–12.6) | 11.3 (10.3–12.1) | 0.90 |
| LPV | 10.7 (9.6–12.0) | 10.7 (9.6–12.0) | 10.5 (9.0–11.9) | 10.9 (10.1–12.0) | 0.50 |
| Ratio diameter RPV/LPV | 1.1 (0.9–1.2) | 1.1 (0.9–1.2) | 1.1 (1.0–1.3) | 1.1 (0.9–1.2) | 0.40 |
| PV branches angulation | |||||
| RPV | 153 (142–163) | 151 (140–162) | 155 (145–168) | 158 (147–164) | 0.20 |
| LPV | 97 (80–115) | 98 (77–113) | 97 (81–118) | 98 (84–116) | 0.80 |
| Predominant PV branchc | 0.50 | ||||
| RPV | 123 (67) | 67 (67) | 43(70) | 13 (57) | |
| LPV | 61 (33) | 33 (33) | 18(30) | 10 (43) | |
| Arterial variations | |||||
| Right hepatic artery | 22 (11) | 13 (12) | 8 (12) | 1 (4.2) | 0.70 |
| Left hepatic artery | 24 (12) | 12 (11) | 8 (12) | 4 (17) | 0.70 |
a
= n (%), median (interquartile range, IQR);
b
= Fisher's exact test, Kruskal-Wallis;
c
= primitive branch of the portal vein presenting the largest cross-sectional area
BMI = body mass index; CRLM = indicates colorectal cancer liver metastasis; LPV = left portal vein; MSI = microsatellite instability; PV = portal vein; RPV = right portal vein