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. 2024 Aug 30;10(17):e36770. doi: 10.1016/j.heliyon.2024.e36770

Fig. 2.

Fig. 2

Univariate and multivariate Logistic regression analysis of predicted MVI in the training dataset (A); Nomogram for predicting MVI based on selected clinical factors in the training dataset (B). Roc curve analysis of predicted nomogram for MVI and other independent predictors in the training dataset (C); The calibration curve (D), decision curve (E), and clinical impact curve (F) of the nomogram in the training dataset.The threshold probabilities for the decision curves range from 17 % to 85 % and the corresponding net returns range from 0.293 to 0.003. It indicates that the nomogram improves the benefit compared with the measures that treat all patients and treat none patient when threshold probability is 17 %–85 %. In the clinical impact curve of 1000 individuals, the red curve (Number high risk) represents the number of patients classified by the nomogram as having a high risk of MVI under each threshold probability; The blue curve (Number high risk with event) represents the actual number of patients with MVI at each threshold probability; Online tools are available at https://dynamic-nomogram-model.shinyapps.io/DNPMVI/(G, Dynamic nomogram for predicting MVI). The black bar represents the low-risk group (AFP,0 ng/mL; Tumor diameter, 20 mm; Tumor number, 1; Tumor margin, Smooth); The blue bar represents the medium-risk group (AFP, 400 ng/mL; Tumor diameter, 50 mm; Tumor number, ≥2; Tumor margin, Smooth); The red bar represents the high-risk group (AFP, 400 ng/mL; Tumor diameter, 80 mm; Tumor number, ≥2; Tumor margin, Non-smooth); Histogram (H) and odds ratio (I) of different risk strata for the nomogram.

MVI, Microvascular invasion; ROC, Receiver operating characteristic; AUC, Area under the curve; OR, Odds ratio; Cl, Confidence interval; AFP, Alpha-fetoprotein; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; GGT, Gamma-glutamyltransferase; Alb, Albumin; TB, Total bilirubin; WBC, White blood cell; CR, Creatinine; PT, Prothrombin time; NLR, Neutrophil-to-lymphocyte ratio; LMR, Lymphocyte-to-monocyte ratio; PLR, Platelet-to-lymphocyte ratio; HBV, Hepatitis B virus.