Table 2.
Birth size by mothers or fathers H19 2992 genotype (ALSPAC cohort)
| Mothers genotype | CC | CT | TT | PA | PD |
| (n = 550) | (n = 242) | (n = 30) | |||
| Weight (gm) | 3457 ± 474 | 3543 ± 508 | 3595 ± 485 | 0.003 | 0.003 |
| Length (cm) | 50.7 ± 2.0 | 51.0 ± 1.9 | 51.1 ± 1.8 | 0.04 | 0.04 |
| Head circ. (cm) | 34.8 ± 1.2 | 35.1 ± 1.3 | 34.9 ± 1.4 | 0.07 | 0.03 |
| (n = 164) | (n = 61) | (n = 9) | |||
| Cord IGF-II (ng/dl) | 266 ± 72 | 312 ± 99 | 312 ± 92 | 0.0003 | 0.0001 |
| Fathers genotype | CC | CT | TT | PA | PD |
| (n = 442) | (n = 201) | (n = 18) | |||
| Weight (gm) | 3492 ± 491 | 3474 ± 472 | 3537 ± 519 | 0.9 | 0.7 |
| Length (cm) | 50.8 ± 1.9 | 50.8 ± 1.9 | 51.1 ± 1.7 | 0.8 | 0.9 |
| Head circ. (cm) | 34.9 ± 1.2 | 34.9 ± 1.2 | 35.0 ± 1.2 | 0.9 | 0.7 |
| (n = 76) | (n = 37) | (n = 3) | |||
| Cord IGF-II (ng/dl) | 270 ± 75 | 290 ± 93 | 245 ± 96 | 0.5 | 1.0 |
Mean ± SD, adjusted for sex, gestation and parity.
PA = P value for additive genetic model (per T allele)
PD = P value for dominant genetic model (CC versus T/*)