Table 2. Frequency of post-COVID-19 acute thromboembolic disorders among aspirin users vs. non-users within 12 months following index date.
| Complete Unmatched Cohort | PSM Matched Cohort* | |||||||
|---|---|---|---|---|---|---|---|---|
| Overall (N = 334,374) | Non- Aspirin (N = 252544) | Aspirin Users (N = 81830) | p-value+ | Overall (N = 163660) | Non- Aspirin (N = 81830) | Aspirin Users (N = 81830) | p-value+ | |
| Any Thromboembolic Disorders | 33925 (10.1%) | 21233 (8.4%) | 12692 (15.5%) | <0.001 | 23643 (14.4%) | 10951 (13.4%) | 12692 (15.5%) | <0.001 |
| Venous Thromboembolic Disorders | ||||||||
| Pulmonary Embolism | 6728 (2.0%) | 5021 (2.0%) | 1707 (2.1%) | 0.223 | 4148 (2.5%) | 2441 (3.0%) | 1707 (2.1%) | <0.001 |
| Deep Vein Thrombosis | 3206 (1.0%) | 2336 (0.9%) | 870 (1.1%) | 0.002 | 1949 (1.2%) | 1079 (1.3%) | 870 (1.1%) | <0.001 |
| Cerebral Venous Sinus Thrombosis | 75 (0.0%) | 53 (0.0%) | 22 (0.0%) | 0.619 | 39 (0.0%) | 17 (0.0%) | 22 (0.0%) | 0.726 |
| Other Venous Thromboembolic Disorders1 | 6289 (1.9%) | 4594 (1.8%) | 1695 (2.1%) | <0.001 | 3947 (2.4%) | 2252 (2.8%) | 1695 (2.1%) | <0.001 |
| Arterial Thromboembolic Disorders | ||||||||
| Ischemic Stroke | 12532 (3.7%) | 6867 (2.7%) | 5665 (6.9%) | <0.001 | 9432 (5.8%) | 3767 (4.6%) | 5665 (6.9%) | <0.001 |
| Ischemic Heart Disease (STEMI/NSTEMI) | 9626 (2.9%) | 5676 (2.2%) | 3950 (4.8%) | <0.001 | 6964 (4.3%) | 3014 (3.7%) | 3950 (4.8%) | <0.001 |
| Other Arterial Thromboembolic Disorders2 | 3314 (1.0%) | 1911 (0.8%) | 1403 (1.7%) | <0.001 | 2472 (1.5%) | 1069 (1.3%) | 1403 (1.7%) | <0.001 |
*Propensity Score Matching (PSM) was performed using the “nearest neighbor” method in R Studio (Version 3.6.2) through the “MatchIt” library, matching on the covariates of age, gender, and the VA’s Care Assessment of Needs (CAN) 1-Year Mortality Score.
+Chi-Sq and T-test used to determine significant associations between groups.
1Other Venous Thromboembolic Disorders includes acute embolism and thrombosis of the axillary, subclavian, internal jugular, superior vena cava, inferior vena cava, renal, and other thoracic veins. Also, acute embolism and thrombosis of other specified deep veins of lower extremities and veins of upper extremities.
2Other Arterial Thromboembolic Disorders includes both arterial embolism and thrombosis, and renal embolism and thrombosis.