TABLE 3.

Independent determinants of HCC (n=208) in 881 individuals in the NAFLD-EPIDEMIC (MASLD) study cohort

	Unadjusted		Model 1		Model 2		Model 3		Model4
	OR, 95% CI	p	OR, 95% CI	p	OR, 95% CI	p	OR, 95% CI	p	OR, 95% CI	p
Age, years	1.11, 1.10–1.13	<0.0001	—	—	—	—	1.10, 1.07–1.12	<0.0001	1.10, 1.07, 1.12	<0.001
Cirrhosis, yes	6.35, 4.31–9.60	<0.0001	—	—	3.50, 2.30–5.43	<0.0001	3.04, 1.85–5.03	<0.0003	2.32, 1.46, 3.73	<0.001
Sex, M	2.87, 2.00–4.20	<0.0001	2.90, 2.00–4.34	<0.0001	3.10, 2.10–4.70	<0.0001	3.80, 2.50–5.90	<0.0001	3.82, 2.51–5.92	<0.001
T2D, yes	3.84, 2.80–5.33	<0.001	2.62, 1.86–3.70	<0.0001	2.33, 1.64–3.33	<0.0001	1.97, 1.35–2.88	0.0004	1.98, 1.36–2.89	<0.001
PRS-5, unit	1.32, 0.70–2.50	0.38	1.44, 0.74–2.82	0.27	1.05, 0.52–2.12	0.88	0.90, 0.43–1.90	0.80	—	0.31
PRS-5, high risk (≥0.495)	0.76,0.55–1.06	0.10	—	—	—	—	—	—	1.22, 0.83–1.80	—
CHIP, yes	3.04, 2.02–4.56	<0.0001	2.08, 1.26–3.26	0.0004	2.00, 1.30–3.15	0.002	1.41, 0.86–2.30	0.17	1.46, 0.89–2.40	0.13

Note: At logistic regression analysis adjusted for the covariates reported in the models. Unadjusted; model 1: adjusted for sex, T2D PRS-5; model 2: further adjusted for cirrhosis; model 3: further adjusted for age at enrollment; model 4 evaluated PRS-5 as a nominal variable, with high-risk PRS being ≥0.495. Abbreviations: CHIP, clonal hematopoiesis of indeterminate potential; PRS-5, Polygenic Risk Score 5; T2D, type 2 diabetes.