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Five phases of the bone remodeling process. The bone surface is covered by lining cells; when mechanical signals and/or microdamage are sensed by osteocytes, bone resorption is initiated by osteoclasts. Osteoblasts derived from hematopoietic stem cells are responsible for reversal and matrix deposition followed by mineralization, after which osteoblasts eventually become bone lining cells or osteocytes.
