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. Author manuscript; available in PMC: 2025 Sep 17.
Published in final edited form as: Biochemistry. 2024 Aug 30;63(18):2380–2389. doi: 10.1021/acs.biochem.4c00357

Table 2.

Half-Lives of IYD Proteolysis by Trypsin in the Presence and Absence of Iodinated Ligandsa

ligand t1/2 (min)b fold change in t1/2
none 10 ± 1
I-Tyr 22 ± 2 2.2
I-tyrosinamide 27 ± 2 2.7
I-tyramine 27 ± 8 2.7
d-I-Tyr 6.2 ± 1.2 0.62
a

Values and error were obtained from fitting two independent measurements to a first-order decay in Origin 6.0.

b

See Figures S5 and S6.