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. Author manuscript; available in PMC: 2025 Sep 17.
Published in final edited form as: Biochemistry. 2024 Aug 30;63(18):2380–2389. doi: 10.1021/acs.biochem.4c00357

Table 3.

Binding of O2N-Tyr Zwitterionic Derivatives to IYDa

A, B Compound kd(μM)b
graphic file with name nihms-2020647-t0002.jpg COO−, NH3+ O2N-Tyr 4.0 ± 0.9
CONH2, NH3+ O2N-tyrosinamide 2.4 ± 0.1
H, NH3+ O2N-tyraminc 280 ± 10
COO−, OH O2N-HPLA 180 ± 4
a

Data represent the average of two independent measurements, and the error represents their range.

b

See Figure S15.