. Author manuscript; available in PMC: 2025 Oct 1.

Published in final edited form as: Pediatr Infect Dis J. 2024 Jun 17;43(10):991–996. doi: 10.1097/INF.0000000000004426

TABLE 3.

Piperacillin PDAE in Different Dosing Groups Based on PMA and PNA

Drug	Organism	MIC Breakpoint (mcg/mL)	Dosing Regimen Based on Age					PDAE (Hours)^a
Drug	Organism	MIC Breakpoint (mcg/mL)	PMA (Weeks)		PNA (Days)	Per Dose and Interval
Piperacillin	Enterobacteriaceae & P. aeruginosa	16		≤29	8–28		100 mg/kg q12h	27 ± 11 (10, 53)
				≤29	29–60		100 mg/kg q8h	25 ± 11 (9, 50)
				30–36	8–14		100 mg/kg q12h	18 ± 7 (6, 34)
				30–36	15–60		100 mg/kg q8h	20 ± 8 (5, 38)
				37–44	8–60		100 mg/kg q8h	13 ± 5 (5, 26)
	Enterobacteriaceae	8		≤29	8–28		100 mg/kg q12h	35 ± 13 (13, 64)
				≤29	29–60		100 mg/kg q8h	32 ± 12 (11, 58)
				30–36	8–14		100 mg/kg q12h	24 ± 9 (8, 42)
				30–36	15–60		100 mg/kg q8h	25 ± 10 (8, 46)
				37–44	8–60		100 mg/kg q8h	18 ± 6 (7, 32)

Numbers represent mean ± standard deviation (95% CI).

CI, confidence interval; MIC, minimum inhibitory concentration; PDAE, post-discontinuation antibiotic exposure; PMA, postmenstrual age; PNA, postnatal age.