Skip to main content
. 2024 Aug 30;89:102019. doi: 10.1016/j.molmet.2024.102019

Figure 6.

Figure 6

Semaglutide and tirzepatide do not alter amyloid beta content in 6-month-old 5XFAD mice. (A, B) Representative images of (A) the cerebral cortex (Cortex) and (B) the hippocampus (Hippo) and subiculum (Sub) brain regions of 5XFAD mice. Right panels in (A) represent magnification of the area of the cerebral cortex highlighted in the left panels. Scale bars in (A) represent 100 μm (left panels) and 10 μm (right panels); scale bar in (B) represents 50 μm. Quantification of plaque intensity in the cerebral cortex (C, D), hippocampus (E, F) and subiculum (G, H) after Thioflavin S staining in 6-month-old 5XFAD and WT-matched female (♀) and male (♂) mice treated with semaglutide (25 nmol/kg), tirzepatide (10 nmol/kg), or vehicle (saline). Data are represented as means ± SD. n = 5–11 in each group of vehicle (Veh)-, semaglutide (Sema)-, or tirzepatide (TZP)-treated mice.